From: Mohit Gupta
Date: Fri, Jan 5, 2007 at 10:09 AM
Subject: Re: Aegis :: Ideas
THE PERSISTENCE OF MEMORY
How the brain records new memories is a central question in neuroscience. One attractive possibility involves a process called longterm potentiation (LTP) that strengthens connections between neurons. Many neuroscientists suspect that LTP is a memory mechanism, but proving it hasn't been easy. Several findings reported this year strongly bolstered the case.http://www.sciencemag.org/cgi/content/full/314/5807/1850a
Online Extras on LTP
Papers and Articles
A. Gruart et al., "Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice," J. Neurosci. 26, 1077 (2006)
J.R. Whitlock et al., "Learning Induces Long-Term Potentiation in the Hippocampus," Science 313, 1093 (2006)
E. Pastalcova et al., "Storage of Spatial Information by the Maintenance Mechanism of LTP," Science 313, 1141 (2006)
T.V.P. Bliss et al., "ZAP and ZIP, a Story to Forget," Science 313, 1058 (2006)
Perspective article highlighting the Whitlock et al. and Pastalcova et al. studies.
T.V.P. Bliss and T. Lomo, "Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path," J. Physiol., 232, 331 (1973) [PubMed Central]
Original article describing LTP in the rabbit hippocampus.
Interesting Web Sites
Learning, Memory, and Long-Term Potentiation
A section from Kimball's Biology Pages.
How Memory Works: Long-Term Potentiation
An overview from B. Dubuc's The Brain From Top to Bottom.
The Molecular Basis of Learning and Memory
A section in the neurobiology unit of Annenberg Media's online textbook Rediscoving Biology.
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